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日本爱知县卓丽圣教授来我所做报告
发布时间:2013/4/9   作者: 未知   来源: 未知   发布人:gly 浏览:0

  
 
 
姓   名         卓 丽圣
性   别         男
出生日期       1971.6.16
工作单位       爱知医科大学医学部  准教授
地   址         日本爱知县长久手市岩作雁又1-1 (邮编480-1195)
电   话         (81) 90-4217-9089
电子邮箱       zhuols@gmail.com
 
 
教育背景
1993年                        浙江大学生物科学与技术系                                       理学士 (生物化学)
2001年                        日本爱知医科大学                                                      博士 (分子医科学)
 
 
主要学术任职
2001.4 – 2003.3         日本长寿科学技术振兴财团                                        博士后研究员
2003.4 – 2004.3         日本科学技术振兴机构                                               博士后研究员
2004.9 –2008.8          日本爱知医科大学分子医科学研究所                          助理教授
2005.12 –2006.3        美国哈佛医学院、Brigham & Women’s Hospital         访问科学家
2008.9 –现在              日本爱知医科大学医学部                                           准教授
 
 
主要研究方向
l         结缔组织的结构和功能(蛋白聚糖,透明质酸及其结合蛋白)
l         炎症机理(关节软骨损伤, 哮喘, 急性肝障碍等)
l         生殖机理
l         肿瘤转移机制
 
 
参加学会
l         国际透明质酸学会
l         日本结缔组织学会
l         日本生化学会
l         日本软骨代谢学会
l         Japan Matrix Club
 
 
 
 
承担国家级科研项目
(1) 2005-2006年度 日本文部科学省科学研究费 青年B (17770095) 项目负责人
项目名称: 血清由来透明质酸结合蛋白(SHAP)转移酶的纯化与鉴定 
2) 2005-2007年度 日本文部科学省科学研究费 基盘B(17370041) 项目分担
项目名称: 透明质酸的功能分子实体、SHAP-透明质酸共价结合复合物的形成机制和功能
(3)2009年度 日本文部科学省科学研究费特定领域研究(17015051) 项目分担
项目名称: 癌转移的糖链生物学
(4)2009-2011年度 日本文部科学省科学研究费 基盘C (21570147) 项目负责人
项目名称: SHAP对CD44-透明质酸相互作用的调控以及在炎症反应中的作用
(5)2011-2014年度 日本文部科学省学术研究助成基金 基盘C(23570148) 项目分担
项目名称: 参与炎症微小环境niche形成的透明质酸-SHAP复合物的合成机制研究
 
 
承担横向联合科研项目
(1)2005年度 日东学术振兴财团海外派遣助成
项目名称: trypstatin对肥大细胞颗粒tryptase活性的抑制作用和生理意义  项目负责人
(2)2007-2010年度 日本生化学工业株式会社委托研究  项目分担
项目名称: SHAP-透明质酸复合物的合成反应以及与炎症等疾病的关系
(3)2008年度 名古屋大学校长经费”跨大学跨专业多糖科学研究据点建设项目”  项目分担
项目名称: SHAP在富含透明质酸细胞外基质构筑和功能表达中的作用
(4)2009年度 财团法人爱惠会教育研究奖励金  项目负责人
项目名称: SHAP-透明质酸复合物的形成机构和生物功能的解析
(5)2009年度 Combi株式会社委托研究   项目分担
项目名称: 酶分解制备燕窝糖胺聚糖及其结构和生理功能的分析
(6)2011-2014年度 日本生化学工业株式会社委托研究  项目分担
项目名称: 1. 骨骼肌损伤后功能性肌肉再生过程中细胞外基质的变化
              2. 骨骼肌损伤后的肌肉组织瘢痕形成以及疼痛和细胞外基质的关系
 
 
 
 
 
 
 
 
 
 
主要研究论文
1.          Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y. Suppression of hyaluronan synthesis alleviates inflammatory response in murine arthritis and in human rheumatoid synovial fibroblasts. Arthritis Rheum. 2013. doi: 10.1002/art.37861. (印刷中)
2.          Urakawa H, Nishida Y, Wasa J, Arai E, Zhuo L, Kimata K, Kozawa E, Futamura N, Ishiguro N. Inhibition of hyaluronan synthesis in breast cancer cells by 4-Methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo. Int J Cancer. 2012, 130(2):454-66.
3.          Arai E, Nishida Y, Wasa J, Urakawa H, Zhuo L, Kimata K, Kozawa E, Futamura N, Ishiguro N. Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo. Br J Cancer. 2011, 105(12):1839-49.
4.          Yabushita H, Iwasaki K, Kanyama K, Obayashi Y, Zhuo L, Itano N, Kimata K, Wakatsuki A. Clinicopathological role of serum-derived hyaluronan-associated protein (SHAP)-hyaluronan complex in endometrial cancer. Obstetrics and Gynecology International, 2011, 2011:739150
5.          Zhuo L, Kimata K. Serum level of SHAP as a disease marker: in comparison with hyaluronan. Trends Glycosci Glyc., 2010, 22(124):80-88.
6.          Zhu L, Zhuo L, Kimata K, Yamaguchi E, Watanabe H, Aronica M, Hascall VC, Baba K. Deficiency of the SHAP-hyaluronan complex enhances airway hyperresponsiveness in a murine model of asthma. Int Arch Allergy Imm, 2010 (In press)
7.          Adair JE, Stober VP, Sobhany M, Zhuo L, Roberts JD, Negishi M, Kimata K, Garantziotis S. Inter-alpha -trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding. J Biol Chem. 2009,284(25):16922-30.
8.          Garantziotis S, Li Z, Potts EN, Kimata K, Zhuo L, Morgan DL, Savani RC, Noble PW, Foster WM, Schwartz DA, Hollingsworth JW. Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. J Biol Chem. 2009, 284(17):11309-17.
9.          Itano N, Zhuo L, Kimata K. Impact of the Hyaluronan-Rich Tumor Microenvironment on Cancer Initiation and Progression. Cancer Sci, 2008, 99(9):1720-5.
10.      Garantziotis S, Zudaire E, Trempus C, Hollingsworth J, Jiang D, Lancaster L, Richardson E, Zhuo L, Cuttitta F, Brown K, Noble P, Kimata K, Schwartz D. Serum inter-a-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injury. Am J Resp Crit Care Med, 2008, 178(9):939-47.
11.      Obayashi Y, Yabushita H, Kanyama K, Noguchi M, Zhuo L, Kimata K, Wakatsuki A. Role of serum-derived hyaluronan-associated protein-hyaluronan complex in ovarian cancer. Oncol Rep. 2008, 19(5):1245-51.
12.      Zhuo L, Kimata K. Structure and function of inter-α-trypsin inhibitor heavy chains. Connect Tissue Res, 2008, 49(5):311-20.
13.      Kishida T, Yabushita H, Wakatsuki A, Zhuo L, Kimata K. Hyaluronan (HA) and serum-derived hyaluronan-associated protein (SHAP)-HA complex as predictive markers of cervical ripening in premature labor. Connect Tissue Res. 2008;49(2):105-8.
14.      Zhu L, Zhuo L, Watanabe H, Kimata K. Equivalent involvement of inter-alpha-trypsin inhibitor heavy chain isoforms in forming covalent complexes with hyaluronan. Connect Tissue Res, 2008, 49(1):48-55.
15.      Garantziotis S, Hollingsworth JW, Ghanayem RB, Timberlake S, Zhuo L, Kimata K, Schwartz DA. Inter-alpha-Trypsin Inhibitor Attenuates Complement Activation and Complement-Induced Lung Injury. J Immunol (2007) 179(6):4187-92.
16.      Zhuo L, Kanamori A, Kannagi R, Itano N, Shen L, Wu J, and  Kimata K. SHAP potentiates the CD44-mediated leukocyte adhesion to hyaluronan substrate. J Biol Chem (2006) 281(29):20303-14.
17.      Wu J, Zhuo L, Wang W. Analysis of co-localization of tumor necrosis-stimulated gene-6 and link protein in cumulus-oocyte complexes of mouse. Chinese J Anatomy (2006) 29(1):48-50.
18.      Shen L, Zhuo L, Okumura A, Ishikawa T, Miyachi M, Owa Y, Ishizawa T, Sugiura N, Nagata Y, Nonami T, Kakumu S, Kimata K. The SHAP-hyaluronan complex in serum from patients with chronic liver diseases caused by hepatitis virus infection. Hepatol Res (2006) 34(3):178-86.
19.      Wu J, Zhuo L, Wang W. CD44 and inter-alpha-trypsin inhibitor expression in the cumulus-oocyte complexes of mice. J Fujian Med Univ (2005) 39(4):367-369.
20.      Yabushita H, Kishida T, Fusano K, Kanyama K, Zhuo L, Itano N, Kimata K, Noguchi M. Role of hyaluronan and hyaluronan synthase in endometrial cancer. Oncol Rep (2005) 13(6):1101-5.
21.      Zhuo L, Hascall VC, and Kimata K. Inter-alpha-trypsin Inhibitor, a Covalent Protein-Glycosaminoglycan-Protein Complex. J Biol Chem (2004) 279(37):38079-82.
22.      Yingsung W, Zhuo L, Mörgelin M, Yoneda M, Kida T, Watanabe H, Ishiguro N, Iwata H, Kimata K, Molecular heterogeneity of the SHAP-hyaluronan complex: Isolation and characterization of the complex in synovial fluid from patients with rheumatoid arthritis. J Biol Chem (2003) 278: 32710-32718.
23.      Tabata I, Nishida Y, Sugiura H, Zhuo L, Yoneda M, Kimata K, Nakashima H and Ishiguro N. A study of inter-alpha-trypsin inhibitor chains expression in liposarcomas. Eur J Surg Oncol (2003) 29(8): 665-9.
24.      Zhuo, L. Salustri, A, and Kimata, K, A physiological function of serum proteoglycan bikunin: the chondroitin sulfate moiety plays a central role. Glycoconjugate J (2003) 19, 241-247.
25.      Zhuo L, Yoneda M, Zhao M, Yingsung W, Yoshida N, Kitagawa Y, Kawamura K, Suzuki T, and Kimata K. Defect in SHAP-hyaluronan complex causes severe female infertility: A study by inactivation of the bikunin gene in mice. J Biol Chem (2001) 276, 7693-7696.
26.      Zuo L. and Kimata K, Cumulus oophorus extracellular matrix: its construction and regulation. Cell Struct Funct (2001) 26, 189-196.
 
 
1.          卓麗聖、木全弘治. 血清蛋白その他の生化学検査-ヒアルロン酸.「内科」111巻6号 特集 「検査値を読む」,2013(印刷中)
2.          卓麗聖、木全弘治. 第3章 細胞周辺環境のための生物医学. 第2節 ヒアルロン酸リッチマトリックス.「ますます重要になる細胞周辺環境の科学技術-細胞の生存、増殖、機能のコントロールから再生医療まで」, 遺伝子医学MOOK別冊. 田畑泰彦編、株式会社メディカルドゥ, p195-200, (2009)
3.          Zhuo L, Salustri A, Atsumi F, Kawano M, Wu J, Shen L, Ogura A, Yasue H, Hascall VC, Kimata K. Role of Serum-derived Hyaluronan-associated Protein in the Construction of Cumulus matrix and Oocyte Maturation. In: Hyaluronan: Structure, Metabolism, Biological Activities and Therapeutic Applications. Editors: E.A. Balazs and V.C. Hascall, Vol II, 732-735, Matrix Biology Institute, New Jersey, USA (2005)
4.          卓麗聖、木全弘治.ヒアルロン酸の構造と機能. In:「糖鎖科学の新展開-その合成法と医療応用のすべて」, eds. 谷口直之、伊藤幸成, NTS社, p40-47 (2005)
5.          Zhuo L, Shen L, Nonogaki T, Wu J, Itano N, Watanabe H, and Kimata K. Chapter 9 Biological function of hyaluronan-SHAP covalent complex. In: Chemistry and Biology of Hyaluronan. (Eds, H. G. Garg & C. A. Hales), pp 205-222, Elsevier Science B.V, Amsterdam, Netherlands (2004)
6.          Yingsung W, Zhuo L, Yoneda M, Ishiguro N, Iwata H, and Kimata K. The covalent complex formation of hyaluronan with heavy chains of inter-alpha-trypsin inhibitor family is important for its functions. In: The Many Faces of Osteoarthritis. (Eds. Hascall, V.C. and Kuettner, K.E.), pp207-212, Birkhauser Verlag Basel, Switzerland (2002)
7.          Zhao M, Yoneda M, Zhuo L, Huang L, Watanabe H, Yamada Y, Nagasawa S, Nishimura H, and Kimata K. Proteoglycan enhances the formation of the SHAP-HA complex and its effect in hyaluronan-rich matrix formation. In: Hyaluronan Vol 1 Chemical, Biochemical and Biological Aspects, (Ed. Kennedy JF, Phillips GO, Williams PA, Hascall VC), Woodhead Publishing Ltd, Cambridge, pp497-500 (2002)
8.          Yoneda, M, Zhao, M, Zhuo, L, Watanabe, H, Yamada, Y, Huang, L, Nagasawa, S, Nishimura, H, Shinomura, T, Isogai, Z, and Kimata, K, Roles of inter-alpha-trypsin inhibitor and hyaluronan-binding proteoglycans in hyaluronan-rich matrix formation. In: New frontiers in Medical Sciences: Redefining Hyaluronan. (Eds. G. Abatangelo & P.H. Weigel), pp21-30, Elsevier Science B.V, Amsterdam (2000)
 
  
 
 
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